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Heart Preserver Aspirin One a day for a healthy heart!


bulletEnteric Coated
bulletThere is no better 81 mg aspirin manufactured
bullet122 pills per bottle (3 bottles per year is 366 pills for full coverage)
bulletDistinctive color and embossed with a heart logo
bulletMade in the USA
bulletInformative web site

Take one per day.  

If you are experiencing a heart attack, please take two of these immediately, and consult your doctor. Your doctor may place you on two tablets a day for 30 days.
To order Heart Preserver Aspirin, click here

Aspirin summary
Taking daily aspirin
What is aspirin
How does aspirin reduce pain?
How does aspirin reduce blood clots?
How does aspirin help the heart?
Who would benefit from aspirin and who would not?
What are some general guidelines for taking aspirin
A brief history of aspirin
Summary

Not only has aspirin been used for over a century to relieve pain, but recent research has also suggested its beneficial role for many heart patients.  The risk-lowering effects of aspirin have been identified in people who already have cardiovascular disease (e.g., coronary artery disease or high blood pressure). For healthy people, the potential cardiovascular benefits of a daily aspirin have yet to be determined.

First, aspirin is used to reduce the risk of heart attack because it prevents the formation of potentially dangerous blood clots. Aspirin’s ability to lower the risk of heart attack may be due to its anti-inflammatory properties. Recent studies suggest that inflammation, which aspirin can reduce, plays a large role in the development of “hardening of the arteries” (atherosclerosis). The C-reactive protein test, a marker for inflammation, has shown elevated levels of this substance in some patients with acute coronary events (e.g., heart attack or unstable angina).

Second, aspirin can reduce damage to the heart during a heart attack. The aspirin should be chewed rather than swallowed, and is best taken within 30 minutes of the onset of the attack.

Third, research has shown aspirin to be helpful in protecting people from strokes and mini-strokes (transient ischemic attacks) caused by blockages in the blood vessels of the brain. However, people are strongly encouraged to talk to their physician before beginning to take aspirin routinely, because aspirin may also increase the risk of another type of stroke (hemorrhagic) caused by bleeding into and around the brain, especially in women.

Aspirin is not for everyone, and it should never take the place of medications or other treatments prescribed by a physician. People are encouraged to speak with their physician about whether aspirin would be helpful for them and, if so, what dosage the physician feels is appropriate.

Taking daily aspirin

In the early 1970s, research studies concerning the cardiovascular benefits of taking one aspirin a day began to appear. These studies suggested that a daily aspirin could help to prevent heart attacks. The evidence seemed to be so compelling that many people started taking a daily aspirin, including cardiologists.

Over the years, additional research not only confirmed the benefit of a daily aspirin, but also illuminated other benefits. Research has suggested that aspirin may help prevent a first attack, a second heart attack, a first stroke or a second stroke. Data from the Nurses' Health Study also suggest that daily aspirin could reduce the risk of colon polyps and colon cancer, and data from the New York University Women’s Health Study suggest that it could reduce the risk of some types of ovarian cancer. Furthermore, the National Health and Nutrition Examination Survey (NHANES) and the National Epidemiologic Follow-up Study found a dramatically reduced rate of esophageal cancer among people who took aspirin even occasionally.

It took some extra time to demonstrate the benefit of daily aspirin with physician volunteers in the 1988 Physicians' Health Study because of the study's requirements. The study was designed so that all physicians would take a daily pill without knowing the ingredients of the pill. The researchers designed the study so that one-half of the physicians would be taking aspirin and the other half would be taking a sugar pill. However, some physicians were already convinced of the value of aspirin and were unwilling to stop taking aspirin daily in order to participate in research where they might be getting a daily sugar pill. Therefore, it was somewhat challenging to recruit physicians who were willing to participate in the study. The lead researcher of the now-famous study, Dr. Charles H. Hennekens, remains committed to educating physicians about this topic. He is currently involved with a continuing education program called, "Aspirin in the Prevention and Treatment of Cardiovascular Disease."

Many cardiologists recommend a daily aspirin as a preventative measure for patients with risk factors such as family history of heart disease, elevated cholesterol, lack of exercise and/or poor eating habits. All patients who have established coronary heart disease also take a daily aspirin, unless there is a contraindication. Because aspirin can increase the risk of bleeding in the gastrointestinal (GI) tract, it may be helpful to take only enteric-coated aspirin, and generally take with food. As for the dose, some studies recommend 81 milligrams (a baby aspirin) and some studies recommend 325 milligrams (an adult aspirin). 81 mg will control platelet aggregation for 24 hours, and it is not beneficial to exceed that dose.

In light of these promising findings for heart patients, the American Heart Association (AHA) currently recommends daily aspirin for "patients who have experienced a myocardial infarction (heart attack), unstable angina, ischemic stroke, or transient ischemic attacks (TIAs or 'little strokes') if not contraindicated." For people who have not yet experienced any of these cardiovascular problems, the AHA stated that the decision should be made on an individual basis with your physician.

Unfortunately, not everyone can take a daily aspirin, even if their physician believes it might be beneficial. Some patients are allergic to aspirin, have ulcer disease, a history of intestinal bleeding or a general bleeding tendency from many possible causes. Furthermore, people taking an anticoagulant such as Coumadin should not take aspirin because both medications increase the risk of bleeding. People taking nonsteroidal anti-inflammatory drugs (NSAIDs) are generally discouraged from taking aspirin. Finally, people should not take aspirin if they are pregnant, hypertensive, allergic to certain medications or about to go in for surgery, unless specifically recommended by their physician.

According to the American Academy of Pediatrics, the United States Surgeon General, the Food and Drug Administration, the Centers for Disease Control and Prevention and the National Reye's Syndrome Foundation, children under 19 should never be given aspirin if they have a fever-causing illness. If they have a viral infection, then taking aspirin could increase their risk of a rare but potentially fatal condition called Reye's syndrome. Products containing aspirin or other words for aspirin (e.g., acetylsalicylate, acetylsalicylic acid, salicylic acid or salicylate) should also be avoided in these young people when a fever is present.

What is aspirin?

For more than 100 years, aspirin has been used as a pain reliever for headaches and other minor aches and pains. According to the United States Food and Drug Administration (FDA), Americans consume over 20 billion tablets a year.

More recently, aspirin has been widely studied in terms of both preventing cardiovascular disease and in managing the conditions of people who have already have heart disease or a history of heart attack. Some of these research findings include the following:
bullet Aspirin therapy in heart attack patients significantly reduces the risk of damage from the ongoing attack, as well as the overall risk of having another one.

bullet Chewing the tablet, rather than swallowing it whole, helps release the medication into the bloodstream faster.

bullet Men are more likely than women to take or to be given aspirin.

bullet Patients over 80 are less likely than others to be prescribed aspirin as a preventive medicine.

bullet Aspirin seems to protect against strokes and transient ischemic attacks (TIAs) caused by blockages in blood vessels in the brain, but can also cause a slight increase in the risk of another kind of stroke (hemorrhagic) caused by bleeding in the brain. Before anyone goes on a regime of taking daily aspirin, even in small doses, they should be sure to discuss such treatment with their physician.
Different studies have found different dosages to be beneficial. Many studies suggest a low daily dose of aspirin (81 milligrams) to be effective in the prevention of heart attack and stroke. Other studies have used regular doses of aspirin (325 milligrams). Generally, there is no additional benefit in taking more than 325 milligrams per day.

Aspirin can be taken orally in tablets or capsules with an enteric coating, which is gentler to the stomach. Aspirin may also be taken in chewing gum form or as suppositories.

How does aspirin reduce pain?

Chemically, aspirin is known as the compound acetylsalicylic acid (ASA). It fights pain and inflammation by blocking the enzyme called cyclooxygenase, or COX. When this enzyme is blocked, the body is less able to produce prostaglandin, which is a chemical that signals an injury and triggers pain. For example, if a person bumps his or her head, the damaged tissue in the head releases chemicals to help the person feel that pain. Some of these chemicals are prostaglandins. Therefore, blocking their production will lessen the pain felt from an injury or body ache. Aspirin does not heal the underlying problem causing the pain (i.e., the wound itself), but it can help reduce the number of pain "alerters" traveling through the nerves to the brain.

How does aspirin prevent blood clots?

Not only does blocking the production of prostaglandin reduce pain, but it also prevents the formation of blood clots. Some prostaglandins cause platelets to bind together and form clots. If prostaglandin production is slowed or inhibited, so too is clot formation. Blood Therefore, aspirin belongs to a group of drugs called antiplatelets. These are non-habit-forming medications that prevent the formation of blood clots by decreasing the ability of the platelets to bind together (platelet aggregation). By helping to prevent blood clots, aspirin helps to prevent blockages in the arteries that can trigger a heart attack.

One type of prostaglandin, thromboxane, is known to be particularly affected by aspirin. Even small doses of aspirin completely stop its production. Research has shown that taking one baby aspirin (81 milligrams) a day for 10 days successfully reduced thromboxane levels. While the platelets were still able to “plug” a wound so the person did not bleed to death, the platelets were less “sticky” and therefore less likely to form blood clots. For up to 10 days after a person discontinued aspirin use, its effects were still obvious.

How can aspirin help the heart?

By helping to prevent blood clots, aspirin helps to maintain adequate blood flow through the arteries, thus lowering the risk of a heart attack in both men and women. Furthermore, aspirin has been found to reduce the damage of a current or past heart attack if taken either during or immediately after the attack. A 1997 study published by the American Heart Association reported that up to 10,000 more people would survive heart attacks each year if they took one aspirin tablet at the first sign of the attack. Of the 1.25 million Americans per year who have heart attacks, only 60 to 80 percent of them receive aspirin while in cardiac crisis.

Along the same lines, aspirin may be used under a physician's guidance to help in the treatment of certain types of chest pain, pressure or discomfort called angina. Aspirin therapy has also been shown to be beneficial for patients who have had angioplasty, coronary bypass surgery or atrial fibrillation.

Who would benefit from aspirin and who would not?

In general, aspirin has been recommended for patients in the following categories:
bullet Those with known coronary artery disease or atherosclerosis

bullet Those who have experienced heart attack or angina

bullet Those who have significant risk factors for heart disease (e.g., smoking, lack of exercise, high levels of cholesterol or triglycerides, diabetes or high blood pressure)

bullet Those who have undergone bypass surgery

bullet Those who have risk factors for a heart attack

bullet Men over the age of 40 and, possibly, women after menopause

bullet Patients with high homocysteine levels or abnormal C-reactive protein test

bullet Patients who have had mini-stroke (Transient ischemic attacks) and/or ischemic strokes
Furthermore, patients who are scheduled for procedures to open blocked arteries (i.e., angioplasty and stenting) may benefit from “super aspirins,” which are given intravenously during cardiac interventional procedures. For these patients, treatment by “super aspirins” cut the risk of death or other major complications by 40 percent. However, when the same drug was given by mouth in pill form, it was not helpful. People who are allergic to aspirin may be given a different antiplatelet called clopidogrel, which is also given to people undergoing catheter-based procedures.

While the findings are certainly promising, aspirin is not for everyone. The best course of therapy always begins with a physical examination and regular medical visits, as well as with a healthy lifestyle. Aspirin therapy works best with individuals whose blood pressure, cholesterol and weight levels are within the normal range. Physicians will often advise patients not to take aspirin if they have certain side effects and/or pre-existing medical conditions. In general, the following people are usually advised against taking aspirin:
bullet Pregnant women, especially during the first and third trimesters. Aspirin can prolong or otherwise complicate delivery.

bullet People who are about to have surgery. Aspirin can promote excessive bleeding and most surgeons request that their patients refrain from taking aspirin for several (generally 10) days before surgery.

bullet Children under 18 who are recovering from chicken pox or the flu. Aspirin has been linked to a rare, potentially fatal disease called Reye syndrome.

bullet Heavy drinkers (three or more drinks per day). Aspirin has been linked to stomach irritation, liver damage and excessive bleeding in such people.

bullet People with chronic intestinal problems, including ulcers, gastritis, inflammatory bowel disease and bleeding conditions.

bullet People taking certain NSAIDs. Many patients can be safely treated with anticoagulants and low dose aspirin.

bullet People with allergies to some medications, including aspirin.

bullet People with uncontrolled high blood pressure (hypertension).
For individuals with no history or significant risk of heart disease, the evidence indicates that aspirin’s best medical benefit is limited to temporary pain relief.

What are some general guidelines for taking aspirin?

Unless the aspirin is coated to be gentler to the stomach (enteric coated), aspirin should be taken with mild food or an antacid to reduce the chance of stomach upset. These coated tablets should not be chewed, crushed or broken unless in case of emergency (e.g., during a heart attack). Unfortunately, some people’s gastrointestinal tracts cannot dissolve coated aspirin, and the aspirin will remain intact until it leaves the body in a bowel movement.

Guidelines for aspirin call for its use as soon as there is knowledge that a heart attack is underway, preferably in the first 30 minutes after its onset. Cardiac patients should be aware that no other pain reliever can be substituted for the purpose of preventing or treating a heart condition. A 1996 survey as part of the Cardiovascular and Arthritis Usage and Attitude Mapping Study suggested that more than 20 percent of people taking a pain reliever for the purpose of heart disease prevention were taking non-aspirin medications that actually provided no cardiovascular benefit.

There are a number of side effects associated with aspirin use that have been reported by some patients. These include the following:
bullet Stomach upset, which could in time lead to ulcers, pain, heartburn, nausea, vomiting, internal bleeding or holes in the stomach or intestines
bullet Stomach damage, possibly indicated by bloody, black or tarry stools or by bloody vomit
bullet Facial swelling (usually indicates an allergy)
bullet Asthma attack (another indicator of allergy)
bullet Ringing in the ears (when taken in high doses)
bullet Risk of bleeding in the brain, a medical emergency that could lead to stroke
Aspirin should never be taken in place of other medications or treatments recommended by a physician. To understand whether aspirin would be helpful, people are encouraged to speak with their physician about related benefits and risks.
A brief history of aspirin

The main pain-relieving chemical in aspirin (salicin) has been used for pain relief since the 5th century B.C. People such as the famous physician Hippocrates discovered that chewing willow bark and leaves, or using them to brew a potion, could help to relieve pain. It was not until the 1800s that researchers were able to identify salicin as the chemical responsible for the pain relief.

After struggling to find a way to offer the benefits of salicin without its stomach-burning properties, aspirin was first presented to the public in 1915. The manufacturing company was Bayer, a German company that lost its patent as part of the Versailles Treaty that ended the First World War. Aspirin got the first letter of its name from the chemical used to make salicin gentler to the stomach (Acetyl chloride). The next four letters came from the plant from which the salicin was derived: Spiraea ulmaria. The last two letters represent the common ending of drug names at the time: in. Aspirin is now one of the most widely used drugs around the world.

 

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